The Teessiders climbed to within three points of Sky Bet Championship leaders Brighton caused by Saturday's 2-1 victory at Nottingham Forest is actually Sunday's visit of Leeds towards the Riverside Stadium ahead, the Spaniard will shuffle his pack.
Keeper Tomas Mejias, defenders Jack Stephens and Tomas Kalas, midfielder Adam Forshaw and striker Kike are amongst those who may benefit, while Uruguayan midfielder Carlos de Pena will an answer to a senior debut after looking at the bench being an unused replacement the last two games.
Karanka features a relatively clean bill of health with only long-term absentees Rhys Williams, Damia Abella and Alex Baptiste missing.
Wolves are minus the suspended Conor Coady following midfielder was sent off against Brighton on the weekend.
The club are determined not to appeal the dismissal after former Huddersfield star Coady saw red carrying out a challenge on Liam Rosenior.
Dave Edwards can also be expected to be out for weeks using a knee injury despite playing all Saturday's 0-0 draw with Brighton.
Goalkeeper Emi Martinez and defenders Scott Golbourne and Kortney Hause can also be doubtful for your trip for the Riverside but are likely to be fit when Wolves get back to Sky Bet Championship action at Preston on Saturday.
