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| O'Neill was hoping how the out-of-favour winger would get some good game-time |
Darron Gibson was an unused sub, while Seamus Coleman was rested to be a precaution as his hamstring is constantly heal. James McCarthy was the only real Irish international involved.
The Premier League side had appeared prone to elimination if the impressive Nick Blackman gave Reading the lead, but after Roberto Martinez changed his team for your second half the superior quality in Everton's squad inspired victory.
Ross Barkley and Gerard Deulofeu struck as soon as the break as Everton marched by way of the last 16.
Elsewhere, Andy King's header inside the second time period of extra-time saw Leicester by means of the fourth round after the 2-1 enlighten West Ham.
The tie looked destined for any penalty shoot-out until King struck.
Mark Hughes saw Peter Crouch score the thing to knock his former club Fulham, using the 34-year-old making just his second addition of the season.
